Pregnancy Interaction

• Not safe to use during pregnancy.
• Rosuvastatin could be hazardous to embryonic development because cholesterol is necessary for the growth of organs.
• There isn't enough safety evidence on Fenofibric Acid/Fenofibrate, and it could hurt a fetus.
• Don't use either drug while breastfeeding because they may both go into breast milk.
• While on therapy, women who can have children should utilize adequate birth control.

Faq For Medicine

Q1: What is the Rosukem-F Plus Tablet used for?
It is used to treat mixed dyslipidemia, which is when a person has high LDL cholesterol and high triglycerides and needs stronger dual therapy.

Q2. Does it work better than Rosuvastatin alone to lower triglycerides?
Yes. Fenofibric acid and fenofibrate decrease triglycerides quite well, which works well with rosuvastatin's effect on LDL.

Q3: Is it okay to take it every day?
Yes, but only under a doctor's supervision because of the risks of muscle poisoning and liver damage.

Q4. Is it okay to drink alcohol while taking this medicine?
Avoid rigorously. Alcohol makes the liver more poisonous and muscles more likely to get hurt.

Q5. How long does it take to see results?
Most people notice a difference in 2 to 4 weeks, although it may take longer for the complete effect to happen.

Q6. What should I do if I forget to take a dose?
Take it when you recall, unless the next dose is close. Don't take twice as much.

Expert Advice

• Take precisely as directed; don't stop taking it all at once.
• Eat less fat, less sugar, and exercise consistently. Don't smoke or drink alcohol.
• Tell us about any urgent symptoms:
• Severe muscle pain, soreness, and black urine (rhabdomyolysis)
• Jaundice and nausea/vomiting that won't go away (liver damage)
• Severe stomach ache (pancreatitis)
• Regular checks are necessary:
• Test for liver function (LFT)
• Kidney function test (KFT)
• Profile of lipids
• Drink enough water to stay hydrated.
• Don't mix with other fibrates unless your doctor says it's okay.

 Side Effects 

• Pain, cramping, or weakening in the muscles
• Headache
• Feeling sick or throwing up
• Pain or discomfort in the stomach
• Tiredness
• Higher levels of liver enzymes
• Serious Side Effects (Get help right away)
• Rhabdomyolysis (serious muscle damage)
• Toxicity in the liver (dark urine and yellow eyes)
• Pancreatitis (severe abdominal pain that spreads to the back)
• Severe allergic responses, such as a rash, swelling, and trouble breathing
• Kidney problems

 How it Works

• Stops HMG-CoA reductase, which lowers the body's cholesterol production.
• Big drop in LDL, VLDL, and triglycerides; HDL goes up.
• Fenofibric Acid and Fenofibrate
• It turns on PPAR-α receptors, which speeds up the breakdown of triglycerides.
• It lowers VLDL, lowers triglycerides, and raises HDL.
• Fenofibric acid is an active form that makes some formulations more bioavailable.
• The effect of both
• Correction of lipids with two targets:
• Rosuvastatin lowers LDL
• Fenofibric part → Lowering triglycerides
• They work together to treat dyslipidemia that is hard to cure or doesn't respond to treatment.

Medicine Interaction

• With drugs that lower lipids:
• Gemfibrozil and other fibrates can cause serious muscle poisoning.
• Taking a lot of statins raises the risk of rhabdomyolysis.
• With blood thinners:
• Warfarin → higher risk of bleeding
• With immunosuppressants:
• Cyclosporine → very bad for the kidneys when taken with fibrates
• When you drink alcohol:
• Increases the risk of liver injury and muscle breakdown a lot
• With antacids (aluminum/magnesium):
• Reduces how much rosuvastatin gets into the body; wait two hours.
• Other:
• Diabetes medications → may change blood sugar levels
• Macrolide antibiotics may make statins more harmful.

 How to Use

• Take once a day or as directed.
• Do not chew or crumble; just swallow whole with water.
• Take with food if you can to avoid stomach problems.
• Keep a regular schedule every day.
• If you miss a dose, take it as soon as possible unless the following one is close.

Uses / Indications

• Mixed dyslipidemia (high LDL and high triglycerides)
• Very high triglycerides
• Patients inadequately managed on monotherapy with statins
• Lowering the risk of heart disease in people who are at high risk
• Raising HDL levels while decreasing LDL and triglycerides at the same time