Pregnancy Interaction

• Metformin
• Generally thought to be safe throughout pregnancy.
• Often used for gestational diabetes under the care of a doctor.
• Teneligliptin
• Not enough data on how safe it is for people.
• Should not be used during pregnancy unless there is no safer option.
• Safety of the Combination
• Because there isn't much information about Teneligliptin, this combo is NOT recommended during pregnancy.
• Both medications may get into breast milk, so only use them if your doctor says it's okay.

Faq For Medicine

Q 1. What do you use this mix for?
To manage blood glucose levels in Type 2 diabetes, particularly when monotherapy is ineffective.

Q2. Will it make my blood sugar low (hypoglycemia)?
Not very common on its own. Risk goes up when paired with: Insulin Glimepiride or other sulfonylureas

Q3. Is it safe for those with kidney problems to take?
If you have severe renal disease (eGFR < 30), don't use metformin.
Teneligliptin can be utilized if your kidneys aren't working well.
The doctor has to make a decision based on the reports.

Q4. Is it okay to consume it on an empty stomach?
It's best to take Metformin with food because it can make your stomach upset or make you feel acidic.

Q 5. Does it make you gain weight?
No. Metformin might help you lose a little weight. Teneligliptin does not affect weight.

Q6. How fast does it work?
Metformin: It takes 1 to 2 weeks for it to work fully. Teneligliptin: levels of sugar go down after a few days.

Expert Advice

• Take the tablet after you eat every time.
• For the best effects, keep up with your diet and exercise.
• Don't drink alcohol; it raises the risk of lactic acidosis (from Metformin).
• Look:
• Sugar during a fast
• Sugar after a meal
• Every three months, check your HbA1c
• Let your doctor know if you have:
• Severe pain in the stomach
• Hard to breathe
• Throwing up
• Very weak
• Rash on the skin
• Don't use this if you have Type 1 diabetes, DKA, or serious liver or kidney damage.
• Taking Metformin for a long time may diminish levels of vitamin B12.

Side Effects

• Often
• Gas or bloating
• Sick to your stomach
• Discomfort in the stomach
• Diarrhea
• Pain in the head
• A little dizzy
• Not as common
• Not being able to poop
• Taste of metal (from Metformin)
• Low sugar when used with other diabetes drugs
• Very serious (rare)
• Lactic acidosis (Metformin)
• Pancreatitis (Teneligliptin)
• High levels of liver enzymes
• Very bad allergic reaction
• If you have ongoing stomach pain or trouble breathing, get help right once.

 How it works

• A) Metformin (Biguanide)
• Lessens the liver's synthesis of glucose
• Makes insulin work better
• Helps muscles take in more glucose
• Stops the intestines from taking in too much glucose
• → Better regulation of fasting and after meals.
• B) Teneligliptin, which stops DPP-4
• Stops the DPP-4 enzyme, which raises the levels of incretin hormones like GLP-1 and GIP.
• Increases insulin release after meals
• Decreases the amount of glucagon released
• ← Effectively controls blood sugar after meals.
• The effect together
• Two ways to regulate blood sugar before and after meals
• Less likely to have low blood sugar
• No gaining weight

Medicine Interaction

• Be careful when using with:
• For Metformin
• Lactic acidosis from alcohol
• Stop taking Metformin for a short time after getting a CT scan with contrast dye.
• Steroids → increase blood sugar
• Diuretics can make you dehydrated.
• Beta-blockers may hide indicators of low blood sugar.
• For Teneligliptin
• Rifampicin → lessens impact
• Insulin and sulfonylureas raise the risk of low blood sugar.
• Advice in General
• Always tell your doctor if you have problems with your kidneys, liver, or heart.

 How to Use

• The usual dose is one tablet once or twice a day, depending on the formulation and what your doctor says.
• Take with food to lessen gastrointestinal problems.
• Do not crush; just swallow whole with water.
• For the greatest sugar control, keep the same time every day.
• If you forget to take a dose, take it quickly, but don't take two doses.
• Keep checking your blood sugar levels on a regular basis.

 Uses / indications

• Diabetes Mellitus Type 2
• High blood sugar after fasting
• A much of sugar after a meal
• Diabetes that isn't under control with only Metformin
• How to stop diabetes complications from getting worse over time:
• Damage to nerves
• Damage to the kidneys
• Damage to the eyes
• Heart problems