Pioz MF G -2 Tablet contains three anti-diabetic medications: glimepiride, metformin, and pioglitazone. When single or dual therapy fails, they employ a variety of approaches to enhance blood sugar management. Glimepiride, a sulfonylurea, works by increasing pancreatic insulin secretion to lower blood glucose levels. Metformin is a biguanide. It works by lowering glucose production in the liver, decreasing glucose absorption in the intestines, and increasing insulin sensitivity. Pioglitazone is a thiazolidinedione that increases insulin sensitivity.