Uses / Indications:
Piofix 15mg Tablet is used in the treatment of type 2 diabetes. It is used in addition to diet and exercise to improve blood sugar control in adults with type 2 diabetes.
Pregnancy interaction:
Piofix 15mg Tablet may be unsafe to use during pregnancy.Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Expert advice:
Piofix helps to control blood sugar level and avoids long-term complications. You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Piofix. Full effect may be visible after several weeks of starting Piofix. Weight gain, headache, and swelling due to fluid build-up may occur. Notify your doctor if you experience shortness of breath, heart problems, or any abnormal swelling. May not be suitable for patients with a history of heart failure or bladder cancer.
Side Effects:
Weight gain, Blurred vision, Respiratory tract infection, Numbness, Bone fracture.
How to use:
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Piofix 15mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
How it works:
Piofix 15mg Tablet is an anti-diabetic medication. It works by increasing the body's sensitivity to insulin, a natural substance that helps control blood sugar levels.
Faq for medicine:
Is Piofix a blood thinner? : No. Piofix is an anti-diabetic medication. Blood thinners are the medicine that prevents the formation of a harmful blood clot. These include medicines like Aspirin, Heparin and Warfarin.|Is Piofix a diuretic? : No. Piofix is not a diuretic. It is used in the treatment of Diabetes Mellitus. Diuretics are those medicine which increases urination.|Can Piofix used in Hepatitis B infection? : Some studies have shown that Piofix may be helpful in preventing Hepatitis B Virus-associated Hepatocellular Cancer (Liver Cancer). However, these findings are still very preliminary and clear role has not been established.|Can Piofix used in Hepatitis C infection? : Piofix has been shown to inhibit Liver Cancer (HCC) recurrence in overweight Hepatitis C Virus-infected diabetic patients. It also improved insulin resistance (a state where the body is resistant to the effects and functions of the insulin hormone) in them.|Can Piofix used along with Vitamin D? : Studies indicate that Vitamin-D combined with Piofix may be more effective in improving Bone Mineral Density and Bone Metabolism than Vitamin-D or Piofix alone in the treatment of Diabetes Mellitus patients with kidney dysfunction (Diabetic Nephropathy).|Can Piofix be used along with sitagliptin? : Combination therapy with Sitagliptin and Piofix leads to a substantial and sustained improvement in glycemic (blood sugar) control compared to the treatment with Piofix alone. This is useful for patients who cannot tolerate Metformin or Sulfonylureas.|Is there any role of Piofix in Alzheimer disease? : Recent evidence suggests that Piofix may be beneficial in Alzheimer's disease (AD), decreasing the cognitive decline early in the disease process. However, larger studies are now in progress to establish the same.|Can Piofix and repaglinide combined in diabetes treatment? : For patients who previously failed oral antidiabetic therapy, the combination of Repaglinide and Piofix have acceptable safety, with greater reductions of glycemic parameters (blood sugar levels) than using either agent alone.|Does Piofix cause urinary bladder tumour? : Large population studies indicate that Piofix is associated with an increased risk of bladder cancer. The absence of an association of bladder cancer with the other drug of the same class, Rosiglitazone, suggests that the increased risk is drug specific and not a class effect.|Can Piofix be used along with glimepiride in diabetes? : Piofix when added to Glimepiride in Patients with Diabetes Mellitus, has been found to significantly reduce plasma lipid levels and significant improvement in blood pressure control related to a reduction in the insulin resistance.|Is Piofix a steroid? : No. Piofix is not a steroid. It is an anti-diabetic medication which belongs to the class of thiazolidinediones.|How to use Piofix? : Piofix is an anti-diabetes drug used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes. Piofix acts as an insulin sensitizer and decreases the extent of insulin resistance in the body too.|How safe is Piofix? : Piofix cardiovascular safety profile compares favourably with that of Rosiglitazone. Piofix has been found to be associated with bladder tumours but causality assessment has not been proved yet.|How does Piofix cause oedema? : Piofix increases the permeability of fluid in tiny blood vessels called capillaries. This results in easier movement of fluids across the membrane and their consequent accumulation, resulting in oedema (puffiness). Also, Piofix causes increased sodium and water reabsorption from the kidney that contributes to the oedema.|How does Piofix cause bladder cancer? : The mechanism behind the link between Piofix use and bladder cancer is still unknown. Studies have suggested that use of Piofix for more than one year results in increased risk of development of tumour of the urinary bladder.|How Piofix protects against atherosclerosis? : Studies in animals have concluded that Piofix improves the elasticity of the aortic wall ( the aorta is a large blood vessel that arises from the heart and supplies oxygenated blood to the rest of the body). This may be a mechanism by which it protects against atherosclerosis, but more studies are needed to confirm this.|Can Piofix be used with insulin? : The addition of Piofix reduces daily insulin dosages, but study findings have not been consistent. Improvement of lipid profiles has also been weak with this combination therapy. Long-term studies are needed before any conclusions can be reached. Combination therapy should be primarily used for patients who achieve an insufficient reduction in blood sugar with insulin alone.|Can Piofix used for dementia? : Findings indicate that Piofix treatment is associated with a reduced dementia risk in Diabetes mellitus patients. Prospective studies are needed to evaluate a possible neuroprotective effect in these patients in an ageing population.|Can Piofix used for infertility? : Piofix may be of use in infertile patients with polycystic ovary syndrome (PCOS) who are resistant to conventional ovulation induction such as by drugs like Clomiphene, Dexamethasone, or Metformin.|Can Piofix used for psoriasis? : The use of Piofix for plaque psoriasis treatment is controversial. Some studies revealed no effect of Piofix 30 mg daily neither on the clinical response of moderate-to-severe psoriasis whereas others demonstrate that it could be considered as an efficacious and safe agent for the treatment of plaque psoriasis.|Can Piofix used for autism? : In a research study in a small number of autistic children, daily treatment with 30 or 60 mg Piofix for 3–4 months induced apparent clinical improvement. Piofix should be considered for further testing of therapeutic potential in autistic patients but as of now, autism is not an approved indication for Piofix use.|Can Piofix be used in depression? : Piofix, either alone or as add-on therapy to conventional treatments, could clinically benefit patients of major depression according to a study.|Can Piofix used for weight loss? : A recent study shows that although Piofix causes a significant decrease in blood sugar, HbA1C and lipid levels, it is associated with weight gain, which would limit its utility. It has not been shown to cause weight loss.|Can Piofix be used to treat fatty liver? : Piofix has also been used to treat non-alcoholic steatohepatitis (fatty liver), but this use is presently considered experimental.|Can Piofix be used for secondary stroke prevention? : Piofix reduces recurrent stroke and major vascular events in stroke patients with insulin resistance, prediabetes, and diabetes mellitus. However, its use as a preventive therapy requires more research.
Medicine interaction:
Piofix with Trimethoprim|Piofix with Lactase|Piofix with Fluoxetine|Piofix with Diacerein|Piofix with Hydrocortisone|Piofix with Dexamethasone|Piofix with Glucosamine|Piofix with Dapoxetine|Piofix with Nicotinic acid / Niacin|Piofix with Triamcinolone|Piofix with Chlorthalidone|Piofix with Deflazacort|Piofix with Fenofibrate|Piofix with Triamterene|Piofix with Propranolol|Piofix with Insulin Glulisine|Piofix with Gemfibrozil|Piofix with Escitalopram|Piofix with Metolazone|Piofix with Rasagiline|Piofix with Budesonide|Piofix with Pancreatin|Piofix with Methylprednisolone|Piofix with Citalopram|Piofix with Pindolol|Piofix with Octreotide acetate|Piofix with Orlistat|Piofix with Insulin Lispro|Piofix with Clonidine|Piofix with Spironolactone|Piofix with Betamethasone|Piofix with Paroxetine
