Colgate Sensitive Pro-Relief contains fluoride that effectively protects teeth from cavities. This protection is as good as standard fluoride anticavity toothpastes. The unique combination of ingredients in Colgate Pro-Relief is exclusive Pro-Argin formula which has arginine and the insoluble calcium compound, calcium carbonate. The Pro-Argin technology provides immediate sensitivity relief and special high cleaning silica abrasive to provide gentle polishing and removal of extrinsic stains. Colgate Pro-Relief provides instant relief with direct application and Lasting relief with daily brushing.Use Colgate Pro-Relief toothpaste twice a day or as directed by a dentist for lasting relief. Use under medical supervision.