Zyzolide 600mg Tablet is an antibiotic prescribed for the treatment of severe bacterial infections. Zyzolide 600mg Tablet works by destroying bacteria that cause serious diseases. It is used to treat a wide range of bacterial diseases, including infections of the lungs (pneumonia), skin, and soft tissues. This medication normally makes you feel better very away, but you should keep taking it as prescribed even after you feel better to ensure that all germs are eliminated and do not grow resistant.