Pregnancy Interaction

• Xylistin 4.5MIU Injection should be used with caution during pregnancy.
• There is insufficient human data about its safety, and animal research are unsatisfactory. The medicine is only given if the possible benefit is greater than the risk to the unborn baby.
• It should also be avoided while breastfeeding because small doses can go into breast milk and hurt the baby's kidneys or stomach. Always talk to your doctor before using this while pregnant or breastfeeding.

Faq For Medicine

Q1. What is the purpose of Xylistin 4.5MIU Injection?

It is used to treat serious infections caused by Gram-negative bacteria that are resistant to several drugs, like Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae.

Q2. Is Xylistin 4.5MIU Injection an antibiotic?

Yes,Xylistin 4.5MIU Injection (also known as Colistin) is a polymyxin antibiotic that kills bacteria by breaking down their cell membranes.

Q3. How is it given?

A doctor gives it to you through an intravenous (IV) injection or infusion, and sometimes through inhalation (nebulization) for lung infections.

Q4. Is it safe for kids to take Xylistin 4.5MIU Injection?

Yes, it can be given to kids with serious illnesses, but the dose is based on their weight and how well their kidneys work.

Q5. Is Xylistin 4.5MIU Injection safe to use for viral infections?

No, it is an antibiotic and does not act against viruses like the flu or the common cold.

Expert Advice

• If you have a confirmed multidrug-resistant infection, only use Colistimethate in a hospital.
• To avoid toxicity, medication levels and kidney function must be checked on a regular basis.
• During treatment, drink plenty of water.
• Do not use with any drugs that are hazardous to the kidneys or the nerves unless it is absolutely necessary.
• Tell someone right away if you have symptoms like tingling, dizziness, weak muscles, or trouble breathing.
• Patients with kidney problems need to have their dose changed.

Side Effects

• Side effects that happen often:
• Feeling sick or throwing up
• Diarrhea
• Itching or a rash on the skin
• Swelling or pain at the site of the injection
• Serious side effects (rare)
• Nephrotoxicity: Damage to the kidneys that makes it harder to urinate
• Neurotoxicity: feeling dizzy, weak muscles, confused, or having convulsions
• Allergic responses might cause a rash, swelling, or trouble breathing.
• If you notice that you are urinating less, your muscles are weak, or you are having trouble breathing, get medical care right away.

 How It Works

• Xylistin 4.5MIU Injection is an antibiotic that belongs to the polymyxin class.
• It binds to the bacterial cell membrane, which changes its shape and lets the contents leak out, killing the bacterium.
• It works very well against Gram-negative bacteria, including those that don't respond to most other antibiotics, such carbapenems.

Medicine Interaction

• Xylistin 4.5MIU Injection  might interact with:
• Aminoglycosides (Amikacin, Gentamicin): Higher chance of renal damage
• Vancomycin: Increased risk of kidney damage
• Neuromuscular blockers: Can lead to extended muscle weakening or paralysis.
• Cephalosporins: Could make kidney problems worse
• Muscle relaxants or anesthetics: More adverse effects on the nerves and muscles
• Always tell your doctor about any vitamins, herbs, or drugs you are taking.

 How to Use

• Given through an IV or by inhaling (nebulization) while under medical supervision.
• The amount you take depends on the kind of illness, your weight, and how well your kidneys work.
• Before giving, it must be mixed with sterile saline.
• Don't inject yourself; always do it under the advice of a healthcare expert.
• Finish the whole course, even if your symptoms go better early, to stop bacteria from becoming resistant.

 Uses / Indications

• Xylistin 4.5MIU Injection is given to people who have:
• Very bad infections that happen in the hospital (particularly in ICU patients)
• Pneumonia associated with a ventilator (VAP)
• Bacteremia or sepsis induced by multidrug-resistant Gram-negative bacteria
• Urinary tract infections (UTIs) resulting from resistant strains
• Intra-abdominal infections and wound infections caused by resistant pathogens
• Inhalation route lung infections in people with cystic fibrosis