Uses / Indications 

• Type 2 Diabetes Mellitus - To help patients who can't regulate their blood sugar well enough with diet and activity
• Combination Therapy: This treatment uses both Metformin (which lowers glucose synthesis in the liver and makes insulin more effective) and Teneligliptin (which blocks DPP-4) to work together.
• Post-Meal Hyperglycemia: This helps lower blood sugar levels after meals.
• Used with diet and exercise as an add-on to lifestyle changes
• Alternative for Monotherapy Failure: Given when single-agent therapy isn't enough

 How it works

• Metformin (1000 mg SR):
• Lessens the liver's ability to make glucose
• Makes muscles and fat tissue more sensitive to insulin
• Lowers blood sugar levels when you don't eat
• Teneligliptin (20 mg):
• Stops the DPP-4 enzyme, which raises incretin hormones
• Makes insulin come out after eating
• Decreases glucagon release, which lowers glucose increases after meals.
• Combination effect: Helps manage blood sugar better and lowers the risk of hypoglycemia compared to some other combinations.

 How to Use

• Take the Sustained Release tablet with food once a day to avoid stomach problems.
• Do not crumble or chew. Just swallow.
• To keep your blood sugar stable, take it at the same time every day.
• Keep an eye on your blood sugar levels often.

Pregnancy Interaction

• Not safe to use during pregnancy, especially metformin, which should only be used under medical supervision; insulin is better.
• There is no proof that teneligliptin is safe to use during pregnancy.
• Breastfeeding should be avoided or conducted under medical supervision.

Side Effects 

• Mild stomach problems include nausea, diarrhea, and bloating (mostly because to metformin)
• Pain in the head
• Nasopharyngitis
• Side Effects That Are Rare or Serious:
• Lactic acidosis (extremely rare but serious, linked to metformin)
• Severe hypoglycemia (especially when used with insulin or sulfonylureas)
• Allergic responses (rash, swelling, and itching)
• Joint pain (rare, because to teneligliptin)
• If you have severe stomach discomfort, are unusually exhausted, are throwing up all the time, or are having trouble breathing, see a doctor right away.

Medicine Interaction

• May work with:
• Sulfonylureas or insulin – higher chance of having low blood sugar
• Cimetidine, contrast dyes, or some heart/kidney medicines can change the levels of metformin or how well the kidneys work.
• CYP3A4 inhibitors/inducers may change the levels of teneligliptin.
• Alcohol raises the risk of lactic acidosis when taken with metformin.
• Always tell your doctor about any supplements, drugs, or herbal products you are taking.

Expert Advice

• Take with food to help your stomach feel better.
• Don't miss doses; it's crucial to keep your blood sugar stable.
• Check your blood sugar levels often.
• Eat well, work out, and drink enough water.
• Tell your doctor if you have any of these symptoms of low blood sugar: sweating, shaking, confusion, or dizziness.
• It is a good idea to have regular kidney function checks.

Faq For Medicine

Q1. Is it okay to take Tenali M with food?
Yes, taking it with food will help your stomach feel better and help your body absorb it better.

Q2. Is it possible for it to lower blood sugar?
When used alone, the risk is low, but it goes up when paired with insulin or sulfonylureas.

Q3. Is it safe for kids to use?
Not usually suggested; youngsters should only use it under a doctor's care.

Q4. Is it okay to drink alcohol while taking it?
Alcohol can raise the risk of lactic acidosis and change blood sugar levels, so don't drink too much.

Q5. Can I quit it when my blood sugar levels are normal?
No, don't stop without talking to your doctor first. Your blood sugar could go up again.