Pregnancy Interaction

• Not Safe or Recommended During Pregnancy
• In general, pregnant women shouldn't take Tacrovera (Tacrolimus) unless it's really necessary. It can cross the placenta and have an effect on the kidneys of the fetus or its overall growth.
• Only use if a professional (a transplant doctor or dermatologist, depending on the reason) tells you to.
• If you use it on your skin, it doesn't get into your body very much, but you should still be careful.
• Always tell your doctor if you are pregnant, want to get pregnant, or have missed your period.

Faq For Medicine

Q1. Is Tacrovera Solution a steroid?

No. It is not a steroid; it is an immunosuppressant (calcineurin inhibitor).

Q2. Is it okay to put Tacrovera Solution on my face?

Yes, if a doctor says so. Tacrolimus is often used to treat atopic dermatitis, eczema, vitiligo, and face dermatitis. Don't use it near your eyes or mouth unless your doctor says it's okay.

Q3. How long does it take to see results?

Usually 1 to 3 weeks, however it depends on the situation.

Q4: Can I stop it all at once?

Do not stop suddenly when using a transplant. You can stop using it for dermatology once your symptoms become better, but only if your doctor tells you to.

Q5. Does it make you want to do it again?

No. It does not make you dependent. Can women who are breastfeeding use it? Topical use: generally safe with care.

Oral/transplant solution: not suggested for nursing.

Q6. Does Tacrovera Solution make you feel like you're burning?

Yes, it's normal to feel a little burning or warmth in the first few days.

Expert Advice

• Don't use it on skin that is damaged, infected, or sunburned unless told to.
• Don't spend too much time in the sun; Tacrolimus can make your skin more sensitive.
• Before and after applying, wash your hands.
• For transplant dosing, take the precise amount at the same time every day. Missing or taking too much can be bad.
• Grapefruit juice can affect the levels of tacrolimus, so don't drink it.
• If you are using a systemic solution, check your kidneys often.
• Don't give this to kids under the suggested age unless a doctor says it's okay.

 Side Effects

• Itching, burning, or redness
• Dry skin
• Feeling of tingling
• Pain in the head
• Feeling sick
• More sensitive to sunlight
• Very serious (Get medical help):
• Systemic kidney dysfunction
• High blood pressure
• Shaking
• Changes in how much urine comes out
• Higher chance of getting infections
• Very bad allergic reactions
• Long-term use (rare, but reported with systemic exposure) can increase the risk of lymphoma and skin cancer.

 How It Works

• Tacrovera (Tacrolimus) is an immunosuppressant that acts by:
• Stopping calcineurin, an enzyme that immune cells need to work.
• Topical usage lessens inflammation and the immunological response in skin disorders.
• Preventing the body from rejecting an organ following a transplant (systemic usage).
• This makes the irritation, redness, and swelling go down.

Medicine Interaction

• Stay away from or use with caution:
• Cyclosporine
• Ketoconazole with Itraconazole
• Clarithromycin with Erythromycin
• Azithromycin (not very often)
• Rifampicin (makes it less effective)
• Phenytoin, Carbamazepine
• Aminoglycoside antibiotics (may make the kidneys more toxic)
• NSAIDs (using them all over the body may hurt your kidneys)
• Grapefruit juice raises the levels of tacrolimus.
• Tell your doctor about all of the medicines you use, even herbal ones.

 How to Use 

• Make sure the area is clean and dry.
• Twice a day (or as directed), put on a thin layer of Tacrovera Solution.
• Only cover with bandages if you are ordered to.
• Don't get in your eyes, mouth, or severe cuts.
• Unless you're treating your hands, wash them after usage.
• Oral/Systemic Solution (for transplant use):
• Use a dosage syringe to measure the dose after shaking it well.
• Take it every day at the same time.
• You can take it with or without food, but you should always do it the same way.
• Don't drink grapefruit juice.

 Uses / Indications

• Uses on the skin:
• Eczema (atopic dermatitis)
• Vitiligo
• Dermatitis from contact
• Dermatitis on the face
• Lichen planus (certain cases)
• Seborrheic dermatitis (not approved)
• Uses for the whole body or mouth:
• Preventing the rejection of organ transplants
• Treatment of graft-versus-host disease (GVHD) — for specialists only