Pregnancy interaction

• Pregnancy Category B – Considered generally safe when prescribed.
• Human studies are limited; however, no confirmed adverse effects have been reported.
• Domperidone
• Limited human data available.
• It should be employed cautiously, particularly during the early stages of pregnancy.
• Refrain from self-medicating; administer medication solely upon the physician's determination that the benefits outweigh the risks.
• General Recommendation
• REBOZEN-DSR should be administered exclusively under medical supervision throughout pregnancy.
• Refrain from habitual or prolonged use without the supervision of a healthcare professional.
• Lactation
• Rabeprazole: Limited transfer into breast milk.
• Domperidone: Transfers into breast milk; may affect prolactin levels.
• Use solely when the breastfeeding mother has been assessed and authorized by a medical professional.

FAQs for Medicine?

Q1. What is the purpose of REBOZEN-DSR?

For conditions such as acidity, indigestion, gastroesophageal reflux disease (GERD), bloating, gas, regurgitation, and nausea.

Q2. What distinguishes DSR from D?

DSR refers to a dual release:

Rabeprazole (enteric-coated)—released within the intestines

Domperidone (SR)—sustained-release formulation for prolonged action

Delivers more potent and prolonged relief.

Q3. At what times should I administer REBOZEN-DSR?

Allow 30 minutes prior to the meal.

Q4. Is it permissible to consume it during the evening hours?

The morning dose is most appropriate. Administer the night dose solely if prescribed to be taken twice daily.

Q5. Is it suitable for prolonged use?

Preferred for a short-term period of 2 to 4 weeks. Prolonged use necessitates the monitoring of vitamins and minerals.

Q6. Is it effective in alleviating vomiting?

Yes, domperidone exhibits anti-nausea and pro-motility effects.

Q7. Is it healthy to address gas and bloating?

Yes, it enhances gastric emptying and alleviates bloating and a sensation of fullness.

Expert advice

• Consume the capsule on an empty stomach to optimize absorption.
• Swallow the entire capsule; do not open, pulverize, or chew.
• Refrain from consuming piquant foods, smoking, alcohol, and carbonated beverages.
• Refrain from lying down promptly following meals.
• Domperidone may influence cardiac rhythm; exercise caution when administering to patients with heart conditions.
• Prolonged use of PPIs may decrease levels of vitamin B12, magnesium, and calcium.
• Report symptoms such as palpitations, severe diarrhea, muscle cramps, or vertigo.
• For persistent acid reflux, a diagnostic assessment may be necessary.

Side Effects

• Headache
• Nausea
• Xerostomia
• Abdominal discomfort
• Gas and bloating
• Vertigo
• Diarrhea or constipation
• Less Frequently Encountered/Serious
• Palpitations / QT interval prolongation (associated with Domperidone)
• Deficiency of magnesium or vitamin B12 resulting from prolonged use of proton pump inhibitors
• Serious rash or allergic responses
• Hormonal fluctuations (breast tenderness and lactation associated with Domperidone)
• Severe gastrointestinal infection (uncommon)

How it works

• Inhibits the H+/K+ ATPase enzyme (proton pump).
• Significant decrease in gastric acid production
• Facilitates the healing of ulcers and esophageal irritation
• Domperidone (30 mg—Sustained Release)
• Inhibits dopamine D2 receptor activity
• Improves the motility of the stomach and intestines
• Alleviates nausea, regurgitation, bloating, and a sensation of fullness
• Synergistic Impact
• Immediate and sustained relief from acidity and reflux
• Enhanced gastric evacuation
• Minimized congestion and discomfort
• Accelerated symptom management in GERD

Medicine Interaction

• Significant Interactions—To Be Avoided With
• Ketoconazole, Itraconazole – diminished absorption
• Erythromycin and Clarithromycin – elevated levels of Domperidone
• Fluconazole – Risk of QT Interval Prolongation
• Cardiac rhythm management medications (Amiodarone, Sotalol)
• Antipsychotic medications—cumulative effects on QT interval
• HIV medications (Atazanavir, Rilpivirine)—diminished efficacy
• Moderate Engagements
• Warfarin – modified clotting risk
• Elevated levels of Digoxin
• High-Dose Methotrexate – Risk of Toxicity
• Nutritional Interaction
• Ideally administered prior to meals.
• Disease Interaction
• Cardiovascular disease
• Liver conditions
• Hypokalemia or hypomagnesemia
• History of gastrointestinal hemorrhage

How to Use

• Take one capsule each day, preferably thirty minutes prior to meals.
• May be administered twice daily in severe cases.
• Swallow the capsule entirely with water.
• Avoid combining with heated beverages.
• In the event of a delayed dose, administer it prior to the subsequent meal; do not take a double dose.
• Complete the full prescribed regimen for optimal results (typically 2–4 weeks).

Uses/Indications

• GERD (Gastroesophageal Reflux Disease)
• Gastroesophageal regurgitation and indigestion
• Repetitive reproduction
• Nausea caused by gastric acidity
• Functional dyspepsia
• Abdominal distension and flatulence
• Peptic Ulcers (Short-Term)
• Postprandial fullness and dyspepsia associated with delayed gastric evacuation