Povifresh 5% Cream is an antiseptic and disinfectant. It is used to treat and prevent infections from wounds and cuts. Povifresh 5% Cream is a multipurpose antiseptic used to treat and prevent infections. Povifresh 5% Cream destroys and inhibits the growth of infection-causing bacteria, preventing abrasions, cuts, wounds, and any other break in the skin from becoming infected. The antiseptic effect is caused by the gradual release of iodine. Keep the afflicted area clean and apply the medication as directed by your doctor.