Pregnancy Interaction

• Not recommended during pregnancy. Ergotamine in Migrafen may decrease uterine blood flow and potentially pose risks to the developing fetus.
• Refrain from use during pregnancy and lactation.
• If a woman becomes expectant while using Migrafen, she should discontinue the medication and seek medical advice promptly.

FAQs for Medicine?

Q1. What is the purpose of Migrafen?

It is employed in the management of acute migraine attacks, with or without aura.

Q2. Is it permissible to consume Migrafen on a daily basis?

No. It is intended for occasional use and should only be administered during migraine episodes.

Q3. What is the rate of its effectiveness?

Migrafen typically begins to take effect within 30 to 60 minutes.

Q4. Is it permissible to administer Migrafen concurrently with pain relievers?

Refrain from combining with other migraine medications or potent analgesics unless explicitly instructed by a healthcare professional.

Q5. Does Migrafen have the potential for addiction?

It is not addictive; however, excessive use may lead to rebound migraines.

Q6. Is Migrafen considered harmless for individuals with hypertension?

Typically contraindicated in uncontrolled hypertension due to ergotamine's potential to induce vasoconstriction.

Expert advice

• Administer Migrafen at the initial onset of migraine symptoms for optimal effectiveness.
• Do not surpass the advised dosage; excessive use may result in severe rebound or medication-overuse headache.
• Refrain from consuming alcohol, tobacco, and beverages high in caffeine, as they may exacerbate blood vessel constriction.
• Not advised for individuals with cardiac disease, hypertension, peripheral vascular disease, or hepatic or renal conditions.
• Refrain from use during pregnancy and lactation.
• If the headache persists without improvement, avoid administering the medication repeatedly—seek medical advice.

Side Effects

Common:

• Nausea
• Emesis
• Vertigo
• Vulnerability
• Gastrointestinal distress

Moderate to Severe:

• Intermittent tingling or numbness in the fingertips and toes
• Chest discomfort or pressure
• Cold extremities
• Elevated blood pressure
• Rapid or sluggish heartbeat
• Intense abdominal discomfort
• Muscular discomfort or spasms
• Reduced blood flow to limbs (rare but critical)
• Seek immediate medical attention if experiencing severe tingling, chest pain, or bluish discoloration of fingers or limbs.

How it works

• Ergotamine constricts the dilated blood vessels in the brain responsible for migraine symptoms.
• Caffeine improves the assimilation and efficacy of ergotamine.
• Together, they diminish the severity of headaches, vertigo, and sensitivity to light and sound during migraine episodes.

Medicine Interaction

• Other medications for migraine (triptans, ergot derivatives)
• Medications for blood pressure (may exacerbate constriction)
• Antibiotics (such as macrolides like erythromycin)—potential risk of ergot toxicity
• Antifungal medications
• HIV pharmacological agents (protease inhibitors)
• Beta-adrenergic blocking agents
• Nicotine and smoking—associated with increased vasoconstriction
• Caffeinated beverages—potential to elevate adverse effects
• Always present your physician with a comprehensive inventory of all your medications.

How to Use

• Begin by taking one tablet at the onset of a migraine attack.
• If symptoms continue, a second dose may be administered after 30 minutes, provided it is advised by a physician.
• Do not surpass the utmost daily dosage specified in your prescription.
• Swallow with water; avoid chewing.
• Not intended for everyday or routine application.

Uses/Indications

• Severe migraine symptoms
• Migraine accompanied by aura
• Cluster headaches (in certain circumstances, under medical supervision)