Pregnancy Interaction

• MESAZED-1200 Tablet contains Mesalazine (Mesalamine) 1200 mg, an anti-inflammatory aminosalicylate employed in the treatment of intestinal inflammation.
• Pregnancy: Typically regarded as safe when conducted under appropriate medical supervision. Human data indicate no substantial fetal injury; however, high doses may elevate the risk of preterm birth or low birth weight. Use solely when explicitly necessary and as directed by a physician.
• Breastfeeding: Mesalazine and its metabolite (N-acetyl mesalazine) may be excreted into breast milk and could potentially induce diarrhea in neonates. Cease breastfeeding should such symptoms manifest.
• Always seek medical advice prior to using MESAZED-1200 during pregnancy or lactation.

FAQs for Medicine?

1. What is the intended purpose of the MESAZED-1200 Tablet?

It is recommended to treat and prevent inflammation associated with intestinal conditions such as ulcerative colitis, Crohn’s disease, and inflammatory bowel disease (IBD).

2. Is it advisable to consume MESAZED-1200 Tablet daily?

Yes, it is frequently prescribed as a daily maintenance medication to manage intestinal inflammation and prevent recurrence.

3. Is it safe to use during pregnancy or breastfeeding?

It may be employed when the advantages surpass the potential risks. Always utilize under medical supervision during pregnancy or while breastfeeding.

4. Is it permissible to consume the MESAZED-1200 Tablet with food?

Certainly. Consuming it after meals with a full glass of water aids in minimizing gastrointestinal irritation.

5. Is it permissible to crush or chew MESAZED-1200 tablets?

No. The tablet features a specialized coating designed to deliver medication directly to the intestine; pulverizing it could diminish its efficacy.

6. Does the MESAZED-1200 tablet effectively treat ulcerative colitis?

It regulates inflammation and sustains remission but does not offer a permanent cure for the disease.

Expert advice

• Always administer MESAZED-1200 Tablet in accordance with your healthcare provider’s instructions; do not discontinue its use abruptly unless explicitly instructed by your physician.
• Swallow entirely with water—do not pulverize or chew.
• Consume an adequate amount of fluids to maintain proper hydration throughout the course of treatment.
• Periodic assessments of kidney and liver function may be required for individuals on prolonged use.
• Refrain from using NSAIDs and consuming excessive alcohol, as they may exacerbate intestinal irritation.
• Notify your physician promptly if you observe hematuria, abnormal fatigue, fever, or an allergic rash.

Side Effects

• Nausea or emesis
• Abdominal discomfort or spasms
• Gas or diarrhea
• Headache or vertigo
• Musculoskeletal discomfort
• Infrequent but potentially significant adverse effects:
• Impairment of renal or hepatic function
• Blood disorders (anemia, leukopenia)
• Hypersensitivity reactions (cutaneous dermatitis, pyrexia, dyspnea)
• If severe symptoms develop, discontinue the medication immediately and seek medical attention without delay.

How it works

• MESAZED-1200 Tablet functions as a localized anti-inflammatory agent within the intestine.
• The active compound, mesalazine (mesalamine), is classified within the aminosalicylate group.
• It suppresses the cyclooxygenase and lipoxygenase pathways, thereby decreasing the synthesis of pro-inflammatory mediators such as prostaglandins and leukotrienes.
• This leads to reduced edema, discomfort, and mucosal injury within the colon.
• It facilitates the maintenance of remission and reduces the risk of relapses in ulcerative colitis and Crohn's disease.

Medicine Interaction

• Azathioprine / 6-Mercaptopurine: May elevate the risk of bone marrow suppression.
• Warfarin: May modify anticoagulant efficacy.
• Corticosteroids: Concurrent use elevates the risk of gastrointestinal irritation.
• NSAIDs (e.g., ibuprofen): May increase the risk of renal toxicity.
• Digoxin: Potentially decreases absorption.
• Notify your physician of all current medications, including supplements and herbal remedies, prior to use.

How to use

• Take the MESAZED-1200 Tablet orally after meals with an ample amount of fluids.
• Refrain from crushing, breaking, or chewing the tablet; consume it whole.
• Administer it at the same time each day to ensure a consistent therapeutic effect.
• If you miss a dose, take it at your earliest convenience—omit it if the scheduled time for the next dose is approaching.
• Proceed with the complete prescribed course of treatment, regardless of symptom improvement.

Uses/Indications

• Ulcerative colitis (acute and remission phases)
• Crohn's disease with colonic involvement
• Inflammatory Bowel Disease (IBD)
• Proctitis / Proctosigmoiditis
• Maintenance of remission in chronic intestinal inflammation