Pregnancy Interaction

MEGABURN-120 Tablet (Orlistat 120 mg) is contraindicated during pregnancy. Weight loss provides no prospective advantage to pregnant women and may adversely affect fetal development. Animal studies have not demonstrated direct teratogenic effects; however, human data remain limited. If a woman becomes expectant while using MEGABURN-120, the medication should be discontinued promptly. Always seek the advice of a gynecologist prior to use during pregnancy or lactation.

FAQs for Medicine?

Q1. What is the intended purpose of MEGABURN-120 Tablet?

It is utilized to support weight loss in individuals who are overweight or obese, in conjunction with a low-calorie, low-fat diet.

Q2. Is it permissible to consume MEGABURN-120 if I omit a meal?

No, if a meal is omitted or lacks fat, you should refrain from taking that dose of MEGABURN-120.

Q3. What is the recommended duration for using MEGABURN-120 Tablet?

It may be utilized for a period of up to six months or longer under medical supervision, contingent upon your weight-loss objectives and progress.

Q4. Does MEGABURN-120 lead to the occurrence of oily stools?

Yes, oily spotting, flatulence with discharge, and loose stools are common adverse effects resulting from the presence of unabsorbed lipids.

Q5. Is it permissible to consume alcohol while using MEGABURN-120?

Alcohol does not have a direct interaction with Orlistat; however, excessive consumption of alcohol may impede weight loss efforts. Utilize in moderation.

Q6. Is MEGABURN-120 considered harmless for individuals with diabetes?

Yes, however, diabetic patients should utilize it under medical supervision, as blood sugar levels may improve, necessitating modifications to antidiabetic medications.

Q7. Is it permissible to take vitamin supplements concurrently with MEGABURN-120?

Yes, it is recommended to take multivitamins containing vitamins A, D, E, and K at bedtime, at least two hours after administering MEGABURN-120, as this may diminish the absorption of fat-soluble vitamins.

Expert advice

• Always administer MEGABURN-120 either immediately before or within one hour following a meal that contains fat.
• Adopt a diet that is limited in calories and fats; meals high in fat may exacerbate gastrointestinal side effects.
• Regularly monitor your body weight and BMI.
• Take daily multivitamins at night to avoid deficiencies of fat-soluble vitamins.
• If you miss a dose, omit it and do not take a double dose.
• Seek medical advice if you encounter severe diarrhea, abdominal pain, or rectal discomfort.
• Engage in consistent physical activity to achieve optimal outcomes.

Side Effects

• Oily discharge or leakage from the rectum
• Presence of flatulence accompanied by oily discharge
• Abdominal discomfort or agony
• Urgent need to defecate or an increase in bowel movements
• Mild or loose diarrhea
• Unusual or infrequent effects:
• Headache
• Anxiety or exhaustion
• Hypoglycemia in patients with diabetes
• Elevated liver enzyme levels (rare)
• Seek medical attention if you encounter severe abdominal pain, jaundice, or enduring diarrhea.

How it works

MEGABURN-120 Tablet contains Orlistat 120 mg, a lipase inhibitor.

It functions locally within the gastrointestinal tract to inhibit the activity of pancreatic and gastric lipases, the enzymes responsible for the digestion of dietary fat. Consequently, approximately 25–30% of dietary fat remains unabsorbed, resulting in decreased caloric intake and progressive weight loss.

Medicine Interaction

• Cyclosporine: Reduced absorption; administer at least three hours apart.
• Levothyroxine: May interfere; administer with a 4-hour interval and observe thyroid function.
• Warfarin / Anticoagulants: May affect vitamin K levels; strictly monitor INR.
• Amiodarone: Potentially diminishes efficacy.
• Antiepileptic medications (e.g., valproate, lamotrigine): May reduce plasma concentrations—monitor for seizure activity.
• Supplements of fat-soluble vitamins (A, D, E, K): Minimized absorption—administer separately at night.

How to Use

• Administer one tablet (120 mg) orally three times daily, concurrent with each principal meal that includes fat.
• Swallow the entire tablet with water; do not pulverize or chew.
• Discontinue a dose if you omit a meal or if the meal contains no fat.
• Maintain a balanced, calorie-conscious diet alongside a consistent exercise regimen.

Uses/Indications

• Management of obesity in individuals with a body mass index of 30 kg/m² or higher
• Individuals with overweight status (BMI > 27 kg/m²) who present risk factors such as diabetes, hypertension, or dyslipidemia
• To support the maintenance of weight following weight loss