Pregnancy Interaction

• LEEZOLE-3 KIT comprises Fluconazole, Azithromycin, and Secnidazole, which are effective against fungal, bacterial, and protozoal infections.
• Fluconazole: Typically not advised during pregnancy, particularly in the first trimester, due to the potential risk of adverse effects on the developing fetus when administered in high concentrations or for extended durations.
• Azithromycin: Regarded as relatively safe during pregnancy when indicated for particular infections.
• Secnidazole: Should be administered with caution during pregnancy, with a preference to avoid use in the first trimester.
• Use solely under medical supervision when the benefits surpass the potential risks. Always seek advice from your gynecologist prior to use.

FAQs for Medicine?

Q1. What is the purpose of LEEZOLE-3 KIT?

It is employed to treat mixed vaginal infections resulting from fungi, bacteria, and protozoa, including symptoms such as vaginal discharge, irritation, and odor.

Q2. What is the number of tablets contained within a single kit?

Each kit typically includes four tablets, each containing specific constituents to be administered in accordance with your doctor's instructions.

Q3. Is it safe to use during pregnancy?

Only with a physician’s prescription. It is not advised during the initial trimester.

Q4. Is it permissible to ingest alcohol while using this medication?

No, alcohol should be rigorously abstained from during and following treatment, as Secnidazole may induce nausea, flushing, and vomiting when combined with alcohol.

Q5. Is LEEZOLE-3 KIT suitable for use by men?

Although originally formulated for women, this combination may also be prescribed to males in specific infections when recommended by a healthcare professional.

Expert advice

• Take the medication precisely as directed, preferable following meals to minimize gastrointestinal discomfort.
• Refrain from consuming alcohol during the course of treatment and for no less than 72 hours following its completion.
• Avoid engaging in sexual activity during treatment to prevent the risk of reinfection.
• Practice proper personal hygiene and wear cotton undergarments.
• Complete the entire course of treatment, even if symptoms diminish prematurely.
• Please inform your healthcare provider if you are pregnant, breastfeeding, or concurrently taking any other antibiotics or antifungal medications.

Side Effects

• Nausea or emesis
• Abdominal distress
• Headache or vertigo
• Metallic sensation in the oral cavity
• Diarrhea or modest abdominal discomfort
• Vaginal discomfort or dampness
• Seek medical care promptly if you encounter severe allergic reactions, including rash, edema, or difficulty breathing.

How it works

• LEEZOLE-3 KIT is a comprehensive combination therapy designed to address various forms of vaginal infections:
• Fluconazole – An antifungal agent that inhibits fungal proliferation by disrupting the integrity of the fungal cell membrane, particularly in Candida species.
• Azithromycin – A macrolide antibiotic that eradicates bacteria by inhibiting protein synthesis.
• Secnidazole – An antiprotozoal and antibacterial agent that inhibits the DNA synthesis of specific bacteria and parasites.
• Together, they offer complete relief from vaginal discharge, itching, stinging, and odor resulting from mixed infections.

Medicine Interaction

• Refrain from consuming alcohol, disulfiram, or other nitroimidazole medications.
• May interact with warfarin or other anticoagulants, increasing the risk of hemorrhage.
• Fluconazole may potentiate the effects of oral hypoglycemic agents, phenytoin, or cyclosporine.
• Refrain from using this medication concurrently with other antifungal or antibiotic treatments unless specifically instructed by your healthcare provider.
• Notify your healthcare provider if you are using hormonal contraceptives, as their effectiveness may be diminished.

How to use

• The kit generally includes four tablets—typically one antifungal (Fluconazole), one antibacterial (Azithromycin), and two antiprotozoals (Secnidazole).
• Please take the tablets in accordance with your doctor's instructions — typically, all tablets are taken together after a meal or according to the prescribed schedule.
• Swallow the tablets entirely with water; refrain from chewing or crushing them.
• Avoid missing dosage or stopping treatment prematurely.
• Ensure adequate hydration throughout the duration.

Uses/Indications

• Mixed vaginal infections (bacterial, fungal, protozoal)
• Vaginal discharge accompanied by pruritus and foul odor
• Trichomoniasis
• Bacterial vaginosis
• Candidal vaginitis
• Pelvic inflammatory infections (in accordance with medical advice)
• Prevention of recurrent infection following vaginal treatment