Pregnancy Interaction

• Use in pregnancy: Itraconazole is not advised during pregnancy unless the infection poses a life-threatening risk and the potential benefits surpass the associated risks.
• Animal studies have indicated potential damage to the developing fetus; therefore, it should be administered solely under rigorous medical supervision. Pregnancy-Related Interaction
• Use during pregnancy: Itraconazole is not advised for use in pregnant women, especially during the first trimester, unless the infection poses a life-threatening risk and no safer treatment options are accessible.
• Animal studies indicate a potential risk to the fetus, with limited data available from human studies. Therefore, it should be administered solely under stringent medical supervision.
• Women of reproductive age are required to utilize effective contraception throughout treatment and to maintain its use for a minimum of one menstrual cycle following the final dose.
• During breastfeeding, itraconazole may be excreted into breast milk in minimal amounts—it should only be used upon the recommendation of a healthcare professional following an assessment of the potential benefits and risks.

How it works

• Itraconazole functions by inhibiting the enzyme lanosterol 14α-demethylase, which is crucial for the biosynthesis of ergosterol, a vital structural element of fungal cell membranes.
• The deficiency of ergosterol results in compromised cell wall integrity and subsequent fungal cell demise.
• It offers comprehensive coverage against dermatophytes, yeasts (Candida spp.), and systemic fungi (Aspergillus, Histoplasma, and Blastomyces).
• It accumulates in keratin-rich tissues such as skin and nails, providing sustained antifungal protection even after the conclusion of therapy.

How to use

• Take the capsule in accordance with your physician's instructions.
• Typically administered following a complete meal to optimize assimilation.
• Swallow the capsule entirely with water—do not pulverize or chew.
• Adhere to a consistent dosing regimen and finish the entire course to prevent the recurrence of infection.
• If you neglect a dose, take it at your earliest convenience unless the scheduled time for the next dose is imminent—under no circumstances should you administer a double dose.
• Store in a calm, dry environment below 30°C, protected from sunlight and humidity.

Uses/Indications

• Fungal skin infections: ringworm (Tinea corporis), athlete’s foot (Tinea pedis), and jock itch (Tinea cruris).
• Fungal Nail Infections (Onychomycosis).
• Vaginal and oral candidiasis (thrush).
• Systemic mycoses: Histoplasmosis, Blastomycosis, and Aspergillosis.
• Seborrheic dermatitis and pityriasis versicolor (fungal dandruff).
• Recurrent or resistant fungal infections unresponsive to topical therapies.

side Effects

Common:

• Nausea, gastrointestinal discomfort, and emesis.
• Headache or vertigo.
• Mild dermatitis or pruritus.
• Constipation or diarrhea.

Uncommon:

• Fatigue and decreased appetite.
• Experiencing bloating or alterations in taste.

Serious (infrequent):

• Liver damage: jaundice of the eyes and skin, dark urine, and ongoing nausea (discontinue medication and seek medical advice).
• Cardiac issues: dyspnea, edema of the ankles, or abrupt weight increase.
• Severe allergic reactions: rash, facial or throat edema, and difficulty breathing (seek urgent medical assistance).

Medicine Interaction

• Itraconazole interacts with various medications; please notify your healthcare provider of all drugs you are presently using.
• Refrain from or exercise prudence when using:
• Antacids and proton pump inhibitors (such as omeprazole and pantoprazole) diminish the absorption of itraconazole.
• Rifampicin, phenytoin, and carbamazepine reduce itraconazole concentrations and therapeutic efficacy.
• Heart rhythm medications (quinidine, dofetilide, cisapride): potential risk of severe cardiac arrhythmia.
• Statins (simvastatin, lovastatin): elevated risk of muscle injury (rhabdomyolysis).
• Oral contraceptives: may marginally decrease contraceptive effectiveness—consider employing supplementary protection.
• Alcohol: abstain completely to prevent liver toxicity.

Expert advice

• Consume after meals to optimize assimilation.
• Do not omit doses or discontinue the course prematurely, even if symptoms show improvement.
• Refrain from consuming alcohol and self-medicating throughout the course of therapy.
• Avoid taking antacids or acid-reducing medications within two hours before or after administering itraconazole.
• Please notify your physician if you have any liver, kidney, or heart conditions.
• For extended treatments such as nail infections, your physician may advise conducting regular liver function tests (LFTs).
• Keep this product out of the reach of minors and store it in a secure manner.

FAQs for Medicine?

Q1. What is the purpose of Itrostred-200?

It is utilized for the treatment of fungal infections affecting the skin, nails, oral cavity, pharynx, and internal organs, including conditions such as ringworm, thrush, and onychomycosis.

Q2. Is it safe to use Itrostred-200 during pregnancy?

No. It should not be administered during pregnancy unless it is absolutely essential and has been prescribed by a medical professional.

Q3. Is it permissible to consume alcohol while taking this medication?

No. Alcohol consumption elevates the risk of hepatic injury and should be abstained from during the course of treatment.

Q4. Is it recommended to consume Itrostred-200 with food?

Yes, it should consistently be administered following meals to optimize absorption and efficacy.

Q5. What steps should I take if I overlook a dose?

Take it promptly upon recall, but omit it if your next dose is imminent. Refrain from duplicating.

Q6. Is vertigo a potential side effect of Itrostred-200?

Yes, moderate dizziness may be experienced. Refrain from driving or operating machinery until you are aware of how it impacts you.

Q7. Is it permissible to use antacids concurrently with this medication?

Refrain from taking antacids within two hours before or after your medication dose, as they diminish drug absorption.

Q8. What is the recommended duration for taking Itrostred-200?

The length of time varies according to the specific type of infection:

Skin infections: 1–4 weeks

Nail infections: a duration of 3 to 6 months

Systemic infections: as directed by your physician

Q9. Is it safe to take Itrostred-200 alongside antibiotics?

Only under medical supervision—itraconazole may interact with specific antibiotics and other antifungal medications.

Q10. Is it necessary to undergo liver function tests during treatment?

Certainly, for extended or recurrent use, your physician may advise regular monitoring of liver function.