Uses / Indications:
Itrostred-100 is used to treat a number of fungal infections. Important signs are:
Superficial fungal diseases (skin, nails) Apollo Pharmacy
Infections of the mucosa or candida, such as oral thrush or esophageal candidiasis
Vaginal yeast infection (in certain combinations or unapproved applications)
Systemic fungal infections (e.g., histoplasmosis, blastomycosis, depending on how bad they are)
Fungal infections of the lungs, nails, and internal organs (in more serious cases)
Pregnancy interaction:
Itraconazole (the active ingredient in Itrostred) is generally not advised during pregnancy unless the possible benefit outweighs the risk to the fetus.
Animal studies have revealed that excessive doses may cause birth defects, but there isn't much data on humans.
If a woman is pregnant or gets pregnant while taking the medicine, she must see a doctor right away.
Be careful while breastfeeding. It could get into breast milk, thus the dangers to the baby should be considered against the advantages to the mother. Some sources say that you should only use it during breastfeeding if you really have to.
Because of this, pregnancy and breastfeeding are essential unique cases that need to be looked at by a doctor and weighed against the risks and benefits.
Expert advice:
Tell your doctor if you have a history of heart disease, liver disease, renal disease, or QT prolongation, or if you are currently taking any drugs before starting Itrostred.
Check liver function tests (LFTs) from time to time during treatment, especially if you are using it for a long time.
Be careful when giving this to those with heart failure because itraconazole may make their hearts work worse.
Don't drive or use machines until you know how the medicine makes you feel (since it can make you dizzy).
Don't drink grapefruit juice with the capsule (it could mess up your metabolism).
Don't stop taking the antibiotic all at once unless you have major side effects. Finish the whole course to lower the danger of the fungus coming back or becoming resistant.
Keep the medicine away from direct light and in a cool, dry location.
Side Effects:
Some common side effects are:
Feeling sick and throwing up
Stomach pain, diarrhea, or other problems with the GI tract
Dizziness and headaches
Elevated liver enzymes (need to be watched)
Some less common yet dangerous side effects are:
Liver toxicity or hepatitis, particularly in those with pre-existing liver conditions.
Problems with the heart (such a negative inotropic effect or potential interactions that cause arrhythmias)
Rare yet serious skin reactions, including Stevens-Johnson syndrome
There have been a few reports of hearing loss with itraconazole, although these are rare.
If you have yellowing of the eyes or skin, dark urine, constant stomach pain, strange bleeding, a severe rash, or trouble breathing, stop taking the medication and consult a doctor very away.
How to use:
Always follow your doctor's instructions when taking Itrostred-100.
You should not crush, chew, or open the capsule; you should swallow it whole.
Taking it with a full meal usually helps it go into the body better.
The kind, intensity, and location of the fungal infection, as well as the patient's age and kidney/liver function, will determine the exact dose and length of time.
If you forget a dose, take it as soon as you remember, unless it's extremely close to the following dose. Don't take two doses to make up for it.
If you take too much, you can feel sick, throw up, or have diarrhea. Get medical care right away.
How it works:
Itraconazole, which is an azole antifungal, is the active ingredient in Itrostred-100.
It acts by stopping the enzyme lanosterol 14α-demethylase from working in fungi. This enzyme is needed to change lanosterol into ergosterol, which is an important part of fungal cell membranes. The fungal cell membrane becomes faulty without ergosterol, which makes it more permeable and breaks down the cell's structure.
This disruption stops the fungus from growing, and eventually, the immune system kills the fungal cells or gets rid of them.
Faq for medicine:
Q1: Is it okay to open the capsule and combine it with food or drink?
No, you should drink the whole capsule. Opening or crushing it could make it less effective or cause more negative effects.
Q2. When should I expect to see progress?
You might see your symptoms become better in a few days, but it usually takes longer for the fungus to go away completely. Even if your symptoms go away early, you should always finish the complete course as your doctor tells you to.
Q3. Is it okay to drink alcohol while taking Itrostred?
Alcohol can put further stress on the liver, which is already being watched while you take itraconazole. It is better to stay away from it or only eat it under a doctor's supervision.
Q4. Does Itrostred make people dependent?
No, itraconazole is not known to be addictive or habit-forming.
Q5. What should I do if my symptoms get worse or new ones appear?
Call your doctor right away. You need to see a doctor right away if you have serious side effects like liver problems, a rash, or jaundice.
Q6. Is it safe for kids to take?
A specialist's opinion is needed because there isn't much research on using it in kids under 12.
Medicine interaction:
Itrostred (itraconazole) has a lot of important interactions since it strongly stops cytochrome P450 (CYP3A4). Here are several points of interaction:
Strong interactions: Certain antiarrhythmics, statins, and ergot alkaloids should not be taken with itraconazole or their doses should be changed.
Benzodiazepines: Taking oral midazolam or triazolam at the same time may make the sedative effects stronger.
Antihistamines: Some, such astemizole, may raise the risk of heart arrhythmias when taken with itraconazole.
Warfarin: Itraconazole may enhance anticoagulant effects, necessitating INR monitoring.
Other antifungals and antimicrobials: Some may cause additive toxicity or change the levels.
Acid suppressants, antacids, and proton pump inhibitors: These may make it harder for your body to absorb itraconazole, so it's crucial to space out the doses.
Interactions with food: Taking it with a full meal is helpful, but you should avoid taking it with things that lower stomach acidity a lot.
Interactions with other diseases: People with heart failure, liver illness, or a high risk of QT prolongation should be careful.
Before starting Itrostred, always tell your doctor about all the medicines you take, including prescription, over-the-counter, and herbal ones.
