Pregnancy Interaction

• Be careful when using it during pregnancy.
• There isn't much research on humans, but animal studies reveal no substantial risk.
• Should only be used when absolutely necessary and when the benefits outweigh the risks.
• During pregnancy, a safer option like ondansetron is usually selected.
• It's not certain if granisetron gets into breast milk a lot, therefore only use it when nursing under the care of a doctor.

Faq For Medicine

Q1. What is the purpose of Granisetron 1 mg?
It is used to stop and cure nausea and vomiting induced by
Chemotherapy
Radiotherapy
Nausea and vomiting after surgery

Q2. Is it more powerful than ondansetron?
Granisetron is frequently the first choice for vomiting caused by chemotherapy since it lasts longer and is stronger.

Q3. Does it make you sleepy?
No, granisetron doesn't normally make you sleepy.

Q4. How quickly does it work?
It normally starts to work 30 to 60 minutes after you take it.

Q5. Can kids take granisetron?
Yes, however the amount you take depends on your weight and must be prescribed by a doctor.

Q6. Can it stop throwing up right away?
It cuts down on vomiting a lot, but it could not halt all of them, depending on how strong the chemotherapy is.

Expert Advice

• Often used before chemotherapy to stop nausea.
• Drink plenty of water to make up for any vomiting.
• Tell the doctor if you have:
• Problems with heart rhythm
• Low potassium and magnesium levels can cause an electrolyte imbalance.
• Disease of the liver
• Don't mix with other medicines that affect serotonin unless you have to.
• Tell us about any symptoms you have, such as:
• Palpitations
• Bad headache
• Feeling dizzy
• Constipation that won't go away

Side Effects

• Often:
• Pain in the head
• Not being able to go to the bathroom
• Weakness
• Feeling dizzy
• Not as Common:
• Not being able to sleep
• Diarrhea
• Pain at the injection location (if given IV)
• Not common, but serious:
• QT prolongation, or an irregular heartbeat
• Serotonin syndrome (rare; occurs with serotonergic medications)
• Allergic symptoms include rashes, swelling, and trouble breathing.

 How It Works

• Granisetron is a specific blocker of the 5-HT3 receptor.
• How it works:
• Stops serotonin from working in the brain and intestines.
• Chemotherapy releases serotonin, which makes you throw up.
• Granisetron stops nausea and vomiting by blocking the activity of serotonin.

Medicine Interaction

• Be careful when using with:
• Medicines that affect serotonin
• (May make serotonin syndrome more likely)
• SSRIs (like sertraline)
• SNRIs (like venlafaxine)
• Tramadol
• Inhibitors of MAO
• Medicines for the heart
• (May make QT prolongation more likely)
• Amiodarone
• Sotalol
• Quinidine
• Other Drugs
• Dexamethasone → can be safely taken with other drugs; may make the effect stronger
• Rifampicin may lower the levels of granisetron.
• There aren't any big food interactions.

 How to Use

• Form: Depending on the prescription, it can be a tablet, syrup, or injectable.
• Before chemotherapy or radiation therapy, or when you throw up, take as directed.
• You can take it with or without food.
• Take it all at once with water.
• If you throw up within an hour of taking the dose, call your doctor (you may need to take the dose again).
• Don't take more than the daily dose that is recommended.
• For injection:
• Only healthcare experts can give it through an IV.

 Uses / indications

• Granisetron 1 mg is used for:
• 1. 1. Chemotherapy-Induced Nausea and Vomiting (CINV)
• Before, during, and after chemotherapy
• 2. Vomiting Caused by Radiation Therapy
• 3. Nausea and vomiting after surgery (PONV)
• 4. Severe vomiting that other drugs can't stop
• (doctor-decided)