Uses / Indications:
Take exactly as prescribed by your doctor.
Generally taken once or twice daily after meals.
Swallow whole with water; do not crush/chew.
If a dose is missed, take it soon unless near next dose (skip missed one).
Do not double the dose.
Short-term use only, unless advised by doctor.
Pregnancy interaction:
First trimester: Should be avoided unless absolutely necessary, as NSAIDs like aceclofenac may interfere with fetal development.
Second trimester: If used, should be for a short duration under strict medical supervision.
Third trimester: Contraindicated, as it may cause:
Premature closure of the ductus arteriosus in the fetus
Reduced amniotic fluid levels
Delayed or prolonged labor
Paracetamol is considered safer in pregnancy, but combination therapy with NSAIDs and enzymes is not routinely recommended.
Serratiopeptidase has insufficient data for pregnancy safety.
Expert advice:
Avoid taking Esgipyrin SP with other painkillers or NSAIDs.
Inform your doctor if you have a history of ulcers, gastritis, asthma, liver or kidney problems.
Do not use if you are on blood thinners unless prescribed with caution.
Drink plenty of fluids to reduce risk of kidney damage.
Do not self-prescribe for more than 5–7 days without consulting a doctor.
Stop immediately and report if you develop black stools, vomiting blood, yellow eyes, or severe stomach pain.
Side Effects:
Mild side effects (common):
Stomach upset, nausea
Diarrhea or constipation
Drowsiness or dizziness
Skin rash
Moderate (less common):
Gastritis or acidity
Heartburn
Swelling of feet/ankles
Serious (rare but important):
Gastrointestinal bleeding (blood in vomit/stool)
Liver toxicity (jaundice, fatigue, dark urine)
Severe allergic reaction (angioedema, difficulty breathing)
Kidney impairment (reduced urine output, swelling)
How to use:
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Esgipyrin SP Tablet is to be taken with food.
How it works:
Aceclofenac: Blocks COX (cyclooxygenase) enzymes → reduces prostaglandins → pain relief + inflammation control.
Paracetamol: Works on brain’s pain and temperature-regulating center → reduces pain and fever.
Serratiopeptidase: Enzyme that breaks down inflammatory proteins → decreases swelling, helps healing, improves antibiotic penetration into tissues.
Together, they provide triple action: analgesic + anti-inflammatory + anti-swelling.
Faq for medicine:
Q1: Can I take Esgipyrin SP for regular headache or fever?
A: No. For simple fever or headache, paracetamol alone is enough. Esgipyrin SP is for pain with inflammation and swelling.
Q2: Is it safe for long-term use?
A: No. Long-term or high-dose use may cause kidney, liver, and stomach complications.
Q3: Can elderly patients use Esgipyrin SP?
A: With caution. Elderly patients are more prone to stomach ulcers, bleeding, and kidney impairment.
Q4: Can I take it on an empty stomach?
A: No, always take it with food to protect the stomach.
Q5: Can it be taken along with antibiotics?
A: Yes, but some antibiotics (like rifampicin) may reduce paracetamol’s effect. Always check with your doctor.
Medicine interaction:
Blood thinners (warfarin, heparin, aspirin, clopidogrel) → increased bleeding risk.
Alcohol → higher risk of stomach ulcers and liver damage.
Other NSAIDs (ibuprofen, diclofenac, naproxen) → additive stomach/kidney side effects.
Corticosteroids (prednisolone, dexamethasone) → higher ulcer risk.
Methotrexate, lithium → levels may increase → toxicity.
Antihypertensives (ACE inhibitors, diuretics) → reduced effect + higher kidney risk.
Certain antibiotics (rifampicin) → lowers paracetamol’s efficacy.
Anticonvulsants (phenytoin, carbamazepine) → increase risk of paracetamol toxicity.
