Pregnancy Interaction

• DAPAFORD-S 100 Tablets contain Dapagliflozin (10 mg) and Sitagliptin (100 mg), used in combination to manage Type 2 Diabetes Mellitus.
• Dapagliflozin is not advised during pregnancy, particularly in the second and third trimesters, due to its potential impact on fetal renal development.
• Sitagliptin lacks sufficient human data regarding safety during pregnancy; animal studies imply potential dangers.
• Therefore, this medicine should not be used during pregnancy or nursing unless given under strict medical supervision when benefits exceed dangers.
• If pregnancy occurs during treatment, the medicine should be discontinued immediately, and a safer alternative like insulin should be considered.

FAQ for Medicine?

Q1. What is DAPAFORD-S 100 used for?

It helps adults with type 2 diabetes mellitus keep their blood sugar levels in check, especially when diet, exercise, and taking one drug aren't enough.

Q2. Can it be used in type 1 diabetes?

No.  It is not suitable for type 1 diabetes or diabetic ketoacidosis (DKA).

Q3.  Is it safe during pregnancy or breastfeeding?

No, it is not recommended during pregnancy or lactation due to potential risks to the baby.

Q4. Can DAPAFORD-S 100 be taken with metformin?

Yes, it can be combined with metformin or other oral antidiabetics if prescribed by a doctor for better glycemic control.

Q5. Does it help with weight loss?

Yes, patients may lose a little weight and have better metabolic control because of how Dapagliflozin works.

Experts advice

• Drink plenty of fluids to avoid dehydration, as dapagliflozin increases urination.
• Maintain adequate genital hygiene to prevent the risk of fungal or urine infections.
• Regularly check blood glucose, kidney, and liver function during treatment.
• Don't drink alcohol because it could make you more likely to get hypoglycemia or dehydration.
• If you have symptoms like vomiting, muscle soreness, weakness, or shortness of breath, you may have ketoacidosis.
• Do not discontinue the medicine abruptly without consulting your doctor.
• Follow a diabetic diet and regular exercise plan to enhance the effects.

Side Effects

• More peeing
• Infection of the urinary tract (UTI)
• Fungal infection of the genitals (itching and discharge)
• Thirst or not drinking enough water
• Headache, dizziness, or fatigue
• Mild stomach upset or nausea
• Serious Side Effects (rare):
• Ketoacidosis (nausea, vomiting, disorientation, and fast breathing)
• Hypoglycemia (especially when combined with insulin or sulfonylureas)
• Low blood pressure due to dehydration
• Kidney damage or less effective kidney function
• Severe allergic reaction (rash, itching, swelling, breathing difficulty)
• Seek medical treatment immediately if you have significant or persistent symptoms.

How It Works

• Dapagliflozin: A SGLT2 inhibitor that helps reduce blood glucose by preventing glucose reabsorption in the kidneys, leading to glucose being excreted through urine.
• Sitagliptin: A DPP-4 inhibitor that increases incretin hormone levels, stimulating insulin secretion and reducing glucose production in the liver.
• Together, they provide dual-action glucose control—dapagliflozin removes excess sugar through urine, while sitagliptin improves insulin function and blood sugar stability.

Medicine Interaction

• Insulin or sulfonylureas (e.g., glimepiride, gliclazide) - increases risk of hypoglycemia.
• Diuretics (furosemide, hydrochlorothiazide) can make you dehydrated and lower your blood pressure.
• ACE inhibitors / ARBs (enalapril, losartan)—may affect kidney function.
• Corticosteroids or thyroid medicines – may alter blood sugar levels.
• Alcohol—increases risk of dehydration and ketoacidosis.
• Always inform your doctor about any ongoing medications, supplements, or herbal products.

 How To Use

• Take one tablet once daily, preferably in the morning, with or without food.
• Do not crush or chew the tablet; just swallow it whole with water.
• Take it at the same time every day for best results.
• If you miss a dose, take it as soon as possible, unless it’s almost time for the next dose—do not double-dose.
• To better manage diabetes, keep eating a balanced diet and working out.

Uses/Indications

• Type 2 Diabetes Mellitus—to improve glycemic control in adults.
• Combination therapy occurs when using only one medicine, such as sitagliptin or dapagliflozin, isn't enough.
• Prevention of diabetic complications—helps reduce the risk of cardiovascular and kidney issues.
• Metabolic benefits – assists in mild weight loss and blood pressure control.