Clofresh OT Cream is a combination medication used to treat a variety of skin infections. Clofresh OT Cream contains a combination of medications used to treat skin infections caused by germs such as bacteria and fungi. Clofresh OT Cream removes infection by destroying and inhibiting the growth of these germs. Clofresh OT Cream also relieves the symptoms of skin infections, such as redness, swelling, and itching. Overall, it promotes skin health and makes you feel better. Even if your symptoms go away, you should continue to take this medication as advised; otherwise, they may return.