Pregnancy Interaction

• Nebivolol (a beta-blocker) and Cilnidipine (a calcium channel blocker) are both in this combination.
• Both should be used with a lot of care while pregnant.
• Beta-blockers could make the fetal heart rate drop, the birth weight drop, and the fetal growth slow down.
• There isn't much information about cilnidipine during pregnancy, however it's not the best choice in the first trimester.
• Only use this if the possible benefit is greater than the danger, and only under a doctor's supervision.
• If you feel dizzy, have a slow heartbeat, or notice less movement from your baby, call your doctor right once.

Faq For Medicine

Q1. What are Nebivolol and Cilnidipine used for?

It is used to treat high blood pressure (hypertension), especially in people who need to lower their heart rate and relax their blood vessels.

Q2. Why mix these two drugs?

Nebivolol slows the heart rate and makes it easier on the heart.

Cilnidipine makes blood vessels bigger and lowers blood pressure without making the heart beat faster.

Together, these help keep blood pressure under control better.

Q3. Can I take it at night?

Yes. You can take it in the morning or at night, but you should do it at the same time every day.

Q4. Will it make my heart rate go down?

Yes. Nebivolol slows down the heart rate. If your heart rate dips below 55 beats per minute, let us know.

Q5. Is this safe for those with diabetes?

Yes, but beta-blockers might hide the signs of low blood sugar, therefore you need to check your sugar levels.

Q6. Does it make your ankles swell?

Cilnidipine may produce minor pedal edema, but not as much as other calcium channel blockers.

Q7. Can I quit taking it right away?

No. Stopping suddenly could cause high blood pressure to go back up.

Expert Advice

• Check your heart rate often.
• To avoid getting dizzy, get up slowly from a sitting or reclining position.
• Stay away from alcohol because it makes you feel more dizzy and lowers your blood pressure even more.
• Do not use if you have asthma or COPD without a doctor's supervision (beta-blocker may make breathing worse).
• It is crucial to check your blood pressure at home on a regular basis.
• Stay away from diets heavy in salt and live a heart-healthy life.
• Tell the doctor before any surgery or dental work.

Side Effects

• Normal:
• Bradycardia is a low heart rate.
• Feeling dizzy
• Pain in the head
• Tiredness
• Swelling in the ankles and feet
• Cold hands and feet
• Not as Common:
• A little shortness of breath
• Pain in the stomach
• Problems with sleep
• Serious (rare):
• Heart rate drops a lot
• Fainting
• Breathing problems, especially for people with asthma
• A bad allergic reaction that causes a rash, edema, and problems breathing
• If you have a bad response, get help right away.

 How It Works

• 2.5 mg of Nebivolol:
• Selective β1-blocker
• Lowers heart rate and workload
• Increases nitric oxide (NO), which causes vasodilation.
• It helps keep blood pressure stable.
• Cilnidipine (10 mg):
• A calcium channel blocker that works on both L-type and N-type channels
• Lowers blood pressure via relaxing blood vessels.
• Less sympathetic activity means a slower heart rate increase.
• All together:
• They drop blood pressure in a controlled and stable way, which puts less stress on the heart.

Medicine Interaction

• Be careful when using with:
• Other BP drugs can make BP drop too low.
• Atenolol and Metoprolol are beta-blockers that slow down the heart rate a lot.
• Calcium channel blockers (Verapamil, Diltiazem) → very slow heart rate
• Antiarrhythmics
• NSAIDs → lower the impact of antihypertensive drugs
• More dizziness from alcohol
• Diabetes medications ← beta-blockers may conceal hypoglycemia.
• CYP3A4 inhibitors and inducers change the levels of cilnidipine.
• Always tell your doctor about all the medicines and supplements you take.

 How to Use

• Take one pill per day, or as directed.
• Do not crumble or chew; just swallow whole with water.
• You can take it with or without food.
• Keep the same time every day.
• If you forget to take a dose:
• Take right away if you remember shortly
• Skip if you're close to your next dose.
• Don't take two doses.
• Keep going for a long time unless your doctor tells you not to.

 Uses / Indications

• High blood pressure (hypertension)
• High blood pressure with:
• Faster heart rate
• BP spikes caused by stress
• Stress on the heart's workload
• Best for people who have:
• Diabetes
• Disease of the kidneys
• Heart illness that doesn't change
• Preventing problems of hypertension, such as:
• Attack on the heart
• Stroke
• Progression of heart failure
• Damage to the kidneys