Uses / Indications:
Pain relief: Headache, dental pain, menstrual cramps, muscle and joint pain.
Inflammation: Arthritis, sprains, strains, minor injuries.
Fever reduction: For flu, colds, or other febrile illnesses.
Pregnancy interaction:
First and second trimester: Occasional use is generally considered low risk.
Third trimester: Avoid use; may cause premature closure of fetal ductus arteriosus, kidney problems, and prolonged labor.
Breastfeeding: Small amounts pass into breast milk; occasional use is generally considered safe.
Expert advice:
Take with water and preferably after meals to reduce stomach irritation.
Avoid alcohol; increases risk of stomach bleeding.
Do not exceed the recommended dose.
Seek medical attention if you experience unusual stomach pain, black/tarry stools, swelling, shortness of breath, or allergic reactions.
Avoid if you have heart disease, kidney disease, or active stomach ulcers unless advised by a doctor.
Side Effects:
Common:
Stomach pain, heartburn, nausea
Headache, dizziness
Mild swelling
Less Common:
Rash, itching
Ringing in ears (tinnitus)
Serious (Seek medical attention):
Severe stomach or abdominal pain
Black or bloody stools
Shortness of breath, swelling of face or throat
Unusual bruising or bleeding
Severe allergic reactions
How to use:
Adults: 400mg every 6–8 hours as needed.
Maximum over-the-counter dose: 1200mg/day unless directed by a doctor.
Take with food or water to reduce stomach irritation.
Swallow tablets whole; do not crush enteric-coated tablets.
Missed dose: Take when needed; do not double next dose.
How it works:
Mechanism of Action:
NSAID (Non-Steroidal Anti-Inflammatory Drug)
Inhibits COX-1 and COX-2 enzymes → reduces prostaglandins → decreases pain, inflammation, and fever.
Pharmacokinetics:
Oral absorption: Rapid
Peak plasma concentration: 1–2 hours
Half-life: 2–4 hours
Metabolism: Liver
Excretion: Kidney
Faq for medicine:
Q1: What is Brufen 400mg Tablet used for?
Treats moderate pain such as headache, dental pain, muscle or joint pain, menstrual cramps.
Reduces inflammation and swelling.
Lowers fever.
Q2: How quickly does it work?
Usually within 30–60 minutes.
Q3: Can I take it on an empty stomach?
You can, but taking it with food or milk reduces stomach irritation.
Q4: Can I take it with other painkillers?
Avoid other NSAIDs (like naproxen) unless prescribed. Paracetamol is generally safe to combine.
Q5: Can I take it daily?
Only under medical supervision; long-term daily use increases risk of gastrointestinal, kidney, and heart problems.
Medicine interaction:
Other NSAIDs: Increased risk of stomach bleeding.
Anticoagulants (warfarin, heparin): Increased bleeding risk.
Diuretics, ACE inhibitors, ARBs: May reduce kidney function.
Lithium: Increased lithium levels → toxicity risk.
Methotrexate: Increased toxicity risk.
Corticosteroids: Higher risk of gastrointestinal bleeding.
