Uses / Indications:
Pain relief (headache, dental pain, muscle/joint pain, menstrual cramps)
Inflammation (arthritis, minor injuries, strains, sprains)
Fever reduction
General pain associated with colds, flu, or minor injuries
Pregnancy interaction:
First and second trimester: Generally considered safe if taken occasionally in low doses.
Third trimester: Avoid use; can cause premature closure of the fetal ductus arteriosus, kidney issues in the fetus, and prolonged labor.
Breastfeeding: Low levels pass into breast milk; occasional use is generally considered safe.
Expert advice:
Take with water, preferably after food to reduce stomach irritation.
Avoid alcohol; it increases risk of stomach bleeding.
Do not exceed recommended dose.
Report unusual stomach pain, black/tarry stools, swelling, or shortness of breath.
Avoid in patients with heart disease, kidney disease, or active stomach ulcers unless prescribed.
Side Effects:
Common:
Stomach pain, nausea, heartburn
Headache, dizziness
Mild swelling
Less common:
Rash, itching
Ringing in ears (rare)
Serious (seek immediate help):
Severe stomach/abdominal pain, black or bloody stools
Shortness of breath, swelling of face or throat
Unusual bruising or bleeding
Severe allergic reaction
How to use:
Adults: Usually 200–400mg every 4–6 hours as needed.
Maximum dose: 1200mg per day (over-the-counter use) unless prescribed otherwise.
Take with food or water.
Swallow tablets whole; do not crush coated tablets.
Missed dose: Take as soon as remembered if still needed; do not double next dose.
How it works:
Mechanism of Action:
Non-steroidal anti-inflammatory drug (NSAID)
Inhibits cyclooxygenase (COX-1 and COX-2) enzymes
Reduces production of prostaglandins → decreases pain, inflammation, and fever
Pharmacokinetics:
Absorption: Rapid oral absorption
Peak plasma: 1–2 hours
Half-life: 2–4 hours
Metabolism: Liver
Excretion: Kidney
Faq for medicine:
Q1: What is Brufen 200mg Tablet used for?
Relieves pain (headache, toothache, menstrual cramps, muscle pain)
Reduces inflammation and swelling
Lowers fever
Q2: How quickly does it work?
Usually within 30–60 minutes after oral intake.
Q3: Can I take it with food?
Yes, taking with food or milk reduces stomach irritation.
Q4: Can I take it with other painkillers?
Avoid combining with other NSAIDs (like naproxen) unless prescribed. Paracetamol is usually safe with Brufen 200mg Tablet
Q5: Can I take it every day?
Only under medical supervision; long-term use can affect stomach, kidneys, and heart.
Medicine interaction:
Other NSAIDs: Increased risk of stomach bleeding
Anticoagulants (warfarin, heparin): Increased bleeding risk
Diuretics, ACE inhibitors, ARBs: May reduce kidney function
Lithium: May increase lithium levels → toxicity
Methotrexate: Increased risk of toxicity
Corticosteroids: Higher risk of gastrointestinal bleeding
