Uses / Indications:
Chronic Heart Failure (HFrEF) - to help people live longer and stay out of the hospital.
Symptomatic heart failure helps with symptoms like shortness of breath, edema, and tiredness.
Alternative therapy to ACE inhibitors or ARBs in patients needing dual mechanism heart protection.
Pregnancy interaction:
50 mg of Azmarda Sacubitril (24 mg) and Valsartan (26 mg) are in the tablet. This combination is used to treat chronic heart failure with a lower ejection fraction (HFrEF).
Pregnancy: ❌ Not safe.
Azmarda should not be taken during pregnancy since it could harm the fetus, cause kidney failure, low amniotic fluid, or even death, especially in the second and third trimesters.
Women who want to get pregnant should cease taking the drug ahead of time.
Stop taking Azmarda right away if you get pregnant while on it and talk to your doctor.
Not suggested to breastfeed. Sacubitril and Valsartan can both get into breast milk and hurt the baby.
Contraception: Women who could get pregnant should use effective birth control while they are on the medicine and for at least a week after they stop using it.
Expert advice:
Do not take ACE inhibitors (such Enalapril or Ramipril) within 36 hours of taking Azmarda. This could cause angioedema, which could be fatal.
Check your blood pressure, potassium levels, and kidney function on a regular basis.
Stay away from foods high in potassium and salt alternatives because they can make your blood potassium levels go up.
If you stop taking your medicine suddenly, it could make your heart failure symptoms worse. Talk to your doctor first.
Stay away from alcohol and dehydration because these can make low blood pressure more likely.
If you have symptoms like swelling in your face, trouble breathing, dizziness, or chest pain, call 911 right once.
Side Effects:
Low blood pressure (hypotension)
Feeling dizzy or passing out
More potassium in the blood (hyperkalemia)
Cough
Tiredness
Lowered kidney function
Serious side effects:
Angioedema (swelling of the lips, tongue, throat, or face)
Very low blood pressure
High potassium causes an irregular pulse.
Function of the kidneys getting worse
If you have any severe or long-lasting effects, stop taking the drug and get medical care right once.
How to use:
Take the pill with a glass of water.
As directed, it can be taken with or without food.
The standard starting dose is one pill twice a day, but this may change depending on the person's health.
For optimal effects, take it at the same time every day.
Don't chew or crush the tablet.
If you forget to take a dose, take it as soon as you remember, unless it's almost time for your next dose. Don't take twice as much.
Keep it in a dry, cool spot where it won't get wet or direct sunlight.
How it works:
The Azmarda 50mg Tablet is a dual-action drug that has:
Sacubitril (inhibitor of neprilysin):
Raises the levels of helpful peptides that assist relax blood vessels, get rid of extra salt, and lower fluid excess.
Enhances circulation and alleviates cardiac workload.
Valsartan (Angiotensin II Receptor Blocker - ARB):
Stops angiotensin II from working, which is a substance that makes blood vessels tighter and raises blood pressure.
Lowers blood pressure and stops the heart from getting worse.
These steps work together to make the heart work better, lower the number of hospital stays, and raise the chances of survival for people with heart failure.
Faq for medicine:
Q1: What is the purpose of Azmarda 50mg Tablet?
It is given to those with chronic heart failure (reduced ejection fraction) to lower their risk of going to the hospital or dying from heart disease.
Q2: Is it safe to use Azmarda if you have high blood pressure?
It may lower blood pressure, but that's not its main usage. It is made just for managing heart failure.
Q3: Is it safe to take Azmarda when pregnant?
No. It is strongly forbidden during pregnancy since it can cause major harm to the unborn baby.
Q4. How long does it take for Azmarda to work?
Within 2 to 4 weeks, symptoms usually go better, but it may take several months of regular use to realize full benefits.
Q5. Is it okay to take Azmarda with food?
Yes. You can take it with or without food, but it's ideal to take it at the same time every day to keep your blood levels stable.
Medicine interaction:
ACE inhibitors (such Enalapril and Ramipril) can cause angioedema, thus keep a 36-hour gap between doses.
Aliskiren raises the risk of kidney problems, especially in people with diabetes.
NSAIDs (such ibuprofen and diclofenac) may make renal function worse.
Taking potassium supplements or salt alternatives can raise your potassium levels too high.
Lithium: raises the risk of lithium poisoning.
Other blood pressure medicines or diuretics could make your blood pressure too low.
Tell your doctor about all the prescription, over-the-counter, and herbal drugs you take.
