Pregnancy Interaction

• Not safe during pregnancy, especially in the second and third trimesters, because of Telmisartan.
• Telmisartan can lead to:
• - not enough amniotic fluid
• - injury to the fetus's kidneys
• – cranium and developmental anomalies
• - limitation of fetal growth
• - fetal death (which is rare but very serious)
• Amlodipine is safer than other drugs, but you should still not take it without medical supervision.
• If you get pregnant, stop right once and tell your doctor.
• Not a good idea while breastfeeding.

Faq For Medicine

Q1. What is the purpose of Amlosafe-TM?
For high blood pressure (hypertension) when one medicine alone isn't adequate.

Q2. When does it start to work?
First effect in 1 to 2 hours
Full BP control in two to four weeks

Q3. Does it make things swell?
Amlodipine could make your feet and ankles swell.

Q4. Can I eat it with food?
Yes, you can take it with or without food.

Q5. Can I stop taking the drug when my blood pressure goes back to normal?
No. Stopping unexpectedly could make your blood pressure go up quickly.

Q 6. Is it okay to drink beer while taking this pill?
Stay away from alcohol; it makes you feel more dizzy and decreases your blood pressure too much.

Q7. Is it safe for people with kidney problems?
Telmisartan protects the kidneys, but you need to keep an eye on your electrolytes.

Expert Advice

• Don't use during pregnancy; use dependable birth control.
• Check your blood pressure on a regular basis.
• You can lower the swelling from amlodipine by eating less salt and raising your legs.
• Stay away from salt substitutes that are high in potassium.
• If you get any of the following, you should report it right away:
• - very bad dizziness
• - feet that are swollen
• – heart palpitations
• – less urination
• - trouble breathing
• Keep making changes to your lifestyle:
• – diet low in sodium
• - working out regularly
• - keeping your weight in check
• - Don't smoke

 Side Effects

• Usually:
• Feeling dizzy
• Feet and ankles swelling
• Headache
• Tiredness
• Low blood pressure
• Pain in the stomach
• Not as Common:
• Heart palpitations
• Muscle spasms
• Flushing
• Problems with sleep
• Very serious (rare):
• A very bad allergic reaction
• Deterioration of kidney function
• Very low blood pressure that makes you faint
• If you start to feel very dizzy, your face swells up, or you have trouble breathing, get medical care right away.

 How It Works

• Telmisartan (ARB):
• Stops angiotensin-II receptors.
• Stops blood vessels from constricting, which makes them relax.
• Lowers blood pressure and protects the heart and kidneys.
• CCB: Amlodipine
• Widening blood vessels by relaxing the walls of arteries.
• Increases blood flow and makes the heart work less.
• The effect of both:
• ✔ A significant and lasting decrease in blood pressure
• ✔ Less risk of heart disease
• ✔ More control than using only one medicine

Medicine Interaction

• Be careful when using with:
• ➤ Potassium supplements or potassium-sparing diuretics
• High potassium risk.
• ➤ Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and diclofenac
• Lower blood pressure regulation and put stress on the kidneys.
• ➤ Other blood pressure medicines
• Could make blood pressure drop too low.
• ➤ Lithium
• The risk of lithium poisoning goes up.
• ➤ Alcohol
• Makes dizziness and low blood pressure worse.
• ➤ Azole antifungals and clarithromycin are CYP3A4 inhibitors.
• Make the concentration of Amlodipine higher.

 How to Use

• Take once a day, at the same time every day.
• You can take it with or without food.
• Take it all in with water.
• If a dose is missed:
• - Take right away if you remember
• – Skip if the next dosage is close by
• – DO NOT double the dose
• Keep going even if you feel OK; your blood pressure needs to be managed for a long time.

Uses / Indications

• High blood pressure (primary hypertension)
• Telmisartan or Amlodipine alone do not regulate BP.
• Patients requiring dual-mechanism blood pressure management
• Avoiding:
• – stroke
• – heart attack
• - damage to the kidneys (particularly in people with diabetes)